Systemic administration of β-glucan induces immune training in microglia

Immune modulating effects of β-glucan.

PURPOSE OF REVIEW To examine the recent scientific literature on the immune modulating effects of β-glucans and subsequent benefits on infection and cancer. RECENT FINDINGS β-Glucans have been investigated for their ability to protect against infection and cancer and more recently for their therapeutic potential when combined with cancer therapy. Their immune modulating effects are attributed...

β - glucan administration enhances disease resistance and some innate 1 immune responses in zebrafish (

Subcutaneous administration of a fusion protein composed of pertussis toxin and filamentous hemagglutinin from Bordetella pertussis induces mucosal and systemic immune responses

Objective(s): After decades of containment, pertussis disease, caused by Bordetella pertussis seems to be re-emerging and still remains a major cause of reported vaccine-preventable deaths worldwide. The current licensed whole-cell vaccines display reactogenicity while acellular vaccines are expensive and do not induce Th1-type immune responses that are required for optimum protection against t...

Irradiated β-glucan enhances immune response to bacterial infection through CD4 and CD8 T-lymphocytes

Background: &beta-glucans are glucose polymers with a variety of stimulatory effects on the immune system. The objective of this study was to evaluate the immune-enhancing activities of low molecular weight gamma irradiated &beta-glucan (I&beta-g) extracted from Pleurotus ostreatus in response to Pseudomonas aeruginosa infection in rats. Materials and Methods: &beta-glucan (&beta-g) powder was ...

β-d-glucan assay in diagnosis and monitoring the systemic candidiasis in a rat model

conclusions while bdg assay seems to be a sensitive and specific adjunctive tool to diagnose and monitor the experimental systemic candidiasis, it seems that measuring the positive cutoff value in different laboratory conditions is necessary for favorable establishment of these tests. results all the infected rats were positive with bdg tests. an increasing level of bdg was observed during earl...